Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors-Reference-Cited by-同舟云学术

Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Published:2013-05-23 Issue:11 Volume:56 Page:4320-4342
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bregman Howard¹,Chakka Nagasree¹,Guzman-Perez Angel¹,Gunaydin Hakan¹,Gu Yan¹,Huang Xin¹,Berry Virginia¹,Liu Jingzhou¹,Teffera Yohannes¹,Huang Liyue¹,Egge Bryan¹,Mullady Erin L.¹,Schneider Steve¹,Andrews Paul S.¹,Mishra Ankita¹,Newcomb John¹,Serafino Randy¹,Strathdee Craig A.¹,Turci Susan M.¹,Wilson Cindy¹,DiMauro Erin F.¹

Affiliation:

1. Department of Chemistry Research and Discovery; ‡Department of Pharmacokinetics and Drug Metabolism; §Oncology Research; ∥Department of Molecular Structure; ⊥Bioassay and Profiling; and ∇Protein Technologies, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4000038

Reference20 articles.

1. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

2. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

3. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

4. APC mutations occur early during colorectal tumorigenesis

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