Correlation between Molecular Mobility and Physical Stability of Amorphous Itraconazole
Author:
Affiliation:
1. Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States
2. Basic Pharmaceutical Sciences, Merck & Co, West Point, Pennsylvania 19486, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp300487u
Reference39 articles.
1. Characterization of the interaction of 2‐hydroxypropyl‐β‐cyclodextrin with itraconazole at pH 2, 4, and 7
2. Characterization of glassy itraconazole: a comparative study of its molecular mobility below Tg with that of structural analogues using MTDSC
3. Characterization of solid dispersions of itraconazole and hydroxypropylmethylcellulose prepared by melt extrusion—part I
4. Increased Physical Stability and Improved Dissolution Properties of Itraconazole, a Class II Drug, by Solid Dispersions that Combine Fast‐ and Slow‐Dissolving Polymers
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