1. Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan, and National Research Institute of Brewing (NRIB), 3-7-1 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan