Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships-Reference-Cited by-同舟云学术

Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships

Published:2008-08-09 Issue:17 Volume:51 Page:5243-5263
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Charifson Paul S.¹,Grillot Anne-Laure¹,Grossman Trudy H.¹,Parsons Jonathan D.¹,Badia Michael¹,Bellon Steve¹,Deininger David D.¹,Drumm Joseph E.¹,Gross Christian H.¹,LeTiran Arnaud¹,Liao Yusheng¹,Mani Nagraj¹,Nicolau David P.¹,Perola Emanuele¹,Ronkin Steven¹,Shannon Dean¹,Swenson Lora L.¹,Tang Qing¹,Tessier Pamela R.¹,Tian Ski-Kai¹,Trudeau Martin¹,Wang Tiansheng¹,Wei Yunyi¹,Zhang Hong¹,Stamos Dean¹

Affiliation:

1. Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, Massachusetts 02139, and Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800318d

Reference39 articles.

1. Antibacterials: are the new entries enough to deal with the emerging resistance problems?

2. The need for new antibiotics

3. Drug‐Resistant Pneumococcal Pneumonia: Clinical Relevance and Related Factors

4. Comparative activity of oral and parenteral cephalosporins tested against multidrug-resistant Streptococcus pneumoniae: report from the SENTRY Antimicrobial Surveillance Program (1997–2003)

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