Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold-Reference-Cited by-同舟云学术

Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold

Published:2013-03-25 Issue:5 Volume:4 Page:491-496
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Jansen Koen¹,Heirbaut Leen¹,Cheng Jonathan D.²,Joossens Jurgen¹,Ryabtsova Oxana¹,Cos Paul³,Maes Louis³,Lambeir Anne-Marie⁴,De Meester Ingrid⁴,Augustyns Koen¹,Van der Veken Pieter¹

Affiliation:

1. Medicinal Chemistry (UAMC), Department of Pharmaceutical Sciences, University of Antwerp (UA), Universiteitsplein 1, B-2610 Antwerp, Belgium

2. Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, United States

3. Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Departments of Pharmaceutical and Biomedical Sciences, University of Antwerp (UA), Universiteitsplein 1, B-2610 Antwerp, Belgium

4. Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp (UA), Universiteitsplein 1, B-2610 Antwerp, Belgium

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300410d

Reference28 articles.

1. Structural and Kinetic Analysis of the Substrate Specificity of Human Fibroblast Activation Protein α

2. Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

3. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

4. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

5. Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth

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