Evaluation of Dynamic Polar Molecular Surface Area as Predictor of Drug Absorption: Comparison with Other Computational and Experimental Predictors-Reference-Cited by-同舟云学术

Evaluation of Dynamic Polar Molecular Surface Area as Predictor of Drug Absorption: Comparison with Other Computational and Experimental Predictors

Published:1998-12-01 Issue:27 Volume:41 Page:5382-5392
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Palm Katrin¹,Luthman Kristina¹,Ungell Anna-Lena¹,Strandlund Gert¹,Beigi Farideh¹,Lundahl Per¹,Artursson Per¹

Affiliation:

1. Department of Pharmacy (Box 580), Department of Organic Pharmaceutical Chemistry (Box 574), and Department of Biochemistry (Box 576), Uppsala University, BMC, SE-751 23 Uppsala, Sweden, and Pharmacokinetics and Drug Metabolism and Medicinal Chemistry, Astra Hässle AB, SE-431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980313t

Reference50 articles.

1. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

2. Comparison between active and passive drug transport in human intestinal epithelial (caco-2) cells in vitro and human jejunum in vivo

3. Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

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