1. Department of Medicinal Chemistry, Division of Pharmacognosy, BMC, Uppsala University, Box 574, S-751 23 Uppsala, Sweden, Pharmnovo Inc., Sahlgrenska Science Park, S-413 46 Gothenburg, Sweden, DECS Global Compound Sciences, AstraZeneca R&D, S-431 83 Mölndal, Sweden, and Division of Biocomputing, MSC11 6145, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131