Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1)-Reference-Cited by-同舟云学术

Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1)

Published:2014-09-07 Issue:18 Volume:57 Page:7687-7701
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sepe Valentina¹,Renga Barbara²,Festa Carmen¹,D’Amore Claudio²,Masullo Dario¹,Cipriani Sabrina²,Di Leva Francesco Saverio¹,Monti Maria Chiara³,Novellino Ettore¹,Limongelli Vittorio¹,Zampella Angela¹,Fiorucci Stefano²

Affiliation:

1. Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano, 49, 80131 Napoli, Italy

2. Department of Clinical and Experimental Medicine, Nuova Facoltà di Medicina, Via Gambuli 1 06132 Perugia, Italy

3. Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano (Salerno), Italy

Funder

PSC Partners Seeking a Cure

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500889f

Reference42 articles.

1. Identification of a Nuclear Receptor for Bile Acids

2. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

3. Vitamin D Receptor As an Intestinal Bile Acid Sensor

4. Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR

Cited by 66 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A modified all-in-one DMSO-activating and base releasing reagent for the Parikh-Doering-type benzylic oxidation reaction;Results in Chemistry;2024-07

2. Investigational farnesoid X receptor agonists for the treatment of primary biliary cholangitis;Expert Opinion on Investigational Drugs;2024-05-07

3. Update on the development of TGR5 agonists for human diseases;European Journal of Medicinal Chemistry;2024-05

4. A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease;2024-04-11

5. The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche;2024-01-24