Preparation and Applications of Xanthenylamide (XAL) Handles for Solid-Phase Synthesis of C-Terminal Peptide Amides under Particularly Mild Conditions1-3

Author:

Han Yongxin1,Bontems Susan L.1,Hegyes Peter1,Munson Mark C.1,Minor Charles A.1,Kates Steven A.1,Albericio Fernando1,Barany George1

Affiliation:

1. Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455, PerSeptive Biosystems Biosearch Products, 500 Old Connecticut Path, Framingham, Massachusetts 01701, and Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference48 articles.

1. Various portions of this work were reported in preliminary form at a variety of venues:  (a) Barany, G.; Albericio, F. InPeptides1990:ProceedingsoftheTwenty-FirstEuropeanPeptideSymposium; Giralt, E., Andreu, D., Eds.; ESCOM Science Publishers:  Leiden, The Netherlands, 1991; pp 139−142. (b) Bontems, R. J.; Hegyes, P.; Bontems, S. L.; Albericio, F.; Barany, G. InPeptides−ChemistryandBiology:ProceedingsoftheTwelfthAmericanPeptideSymposium; Smith, J. A., Rivier, J. E., Eds.; ESCOM:  Leiden, The Netherlands 1992; pp 601−602. (c) Han, Y.; Munson, M. C.; Albericio, F.; Barany, G. InPeptides−BiologyandChemistry:Proceedingsofthe1992ChinesePeptideSymposium; Du, Y.c., Tam, J. P., Zhang,Y.s., Eds.; ESCOM Science Publishers:  Leiden, The Netherlands, 1993; pp 301−304. (d) Han Y.; Barany, G. InInnovationandPerspectivesinSolidPhaseSynthesis&ComplementaryTechnologies:Biological&BiomedicalApplication;Epton, R., Ed.; Mayflower Worldwide Ltd.  Birmingham, England, 1994; pp 525−526. (e) Kates, S. A.; Minor, C. A.; Albericio, F.; Han, Y.; Barany, G. InPeptides1994:ProceedingsoftheTwenty-ThirdEuropeanPeptideSymposium;Maia, H., Ed.; ESCOM Science Publishers:  Leiden, The Netherlands, 1995; pp 262−264.

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