Bispecific Antibodies as Novel Bioconjugates

Author:

Cao Y.1,Suresh M. R.1

Affiliation:

1. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada, T6G 2N8

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Reference119 articles.

1. Monoclonal antibody targeting of methotrexate (MTX) against MTX-resistant tumour cell lines

2. Anderson, P. M., Crist, W., Hasz, D., Carroll, A. J., Myers, D. E., and Uckun, F. M. (1992) G19.4(alpha CD3) x B43(alpha CD19) monoclonal antibody heteroconjugate triggers CD19 antigen-specific lysis of t(4;11) acute lymphoblastic leukemia cells by activated CD3 antigen-positive cytotoxic T cells.Blood80, 2826−34.

3. Development of a bispecific monoclonal antibody for use in molecular hybridisation

4. Azuma, A., Yagita, H., Matsuda, H., Okumura, K., and Niitani, H. (1992) Induction of intercellular adhesion molecule 1 on small cell lung carcinoma cell lines by gamma-interferon enhances spontaneous and bispecific anti-CD3 x antitumor antibody-directed lymphokine activated killer cell cytotoxicity.Cancer Res.52, 4890−94.

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