3- and 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human Cytochrome P45017α (17α-Hydroxylase/C17,20-Lyase). Potential Nonsteroidal Agents for the Treatment of Prostatic Cancer-Reference-Cited by-同舟云学术

3- and 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human Cytochrome P45017α (17α-Hydroxylase/C17,20-Lyase). Potential Nonsteroidal Agents for the Treatment of Prostatic Cancer

Published:1996-01-01 Issue:17 Volume:39 Page:3319-3323
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chan Ferdinand C. Y.¹,Potter Gerard A.¹,Barrie S. Elaine¹,Haynes Benjamin P.¹,Rowlands Martin G.¹,Houghton John¹,Jarman Michael¹

Affiliation:

1. Cancer Research Campaign Centre for Cancer Therapeutics at the Institute of Cancer Research, Cancer Research Campaign Laboratory, 15 Cotswold Road, Sutton, Surrey SM2 5NG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm950749y

Reference14 articles.

1. Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid

2. Esters of 3-Pyridylacetic Acid That Combine Potent Inhibition of 17.alpha.-Hydroxylase/C17,20-Lyase (Cytochrome P45017.alpha.) with Resistance to Esterase Hydrolysis

3. Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C-2 position

4. Racemisation of drug enantiomers by benzylic proton abstraction at physiological pH

5. The reduction of oximes by lithium aluminum hydride in hexamethylphosphoramide solvent

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