Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1)-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1)

Published:2014-10-16 Issue:21 Volume:57 Page:9065-9077
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bonifazi Alessandro¹,Yano Hideaki²,Del Bello Fabio¹,Farande Aniket¹,Quaglia Wilma¹,Petrelli Riccardo¹,Matucci Rosanna³,Nesi Marta³,Vistoli Giulio⁴,Ferré Sergi²,Piergentili Alessandro¹

Affiliation:

1. Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy

2. Integrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, 333 Cassell Drive, Baltimore, Maryland 21224, United States

3. Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA), Università di Firenze, Viale G. Pieraccini 6, 50139 Firenze, Italy

4. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy

Funder

Japan Society for the Promotion of Science London

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501173q

Reference39 articles.

1. Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder

2. Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus