1. Department of Chemistry, National Cheng Kung University, No. 1 University Road, Tainan City, Taiwan, Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 30013, Taiwan, Department of Internal Medicine, National Cheng Kung University, Tainan City, Taiwan, and Institute of Oral Medicine and Department of Stomatology, National Cheng Kung University, Tainan City, Taiwan