Structure-Aided Design of Novel Inhibitors of HIV Protease Based on a Benzodiazepine Scaffold-Reference-Cited by-同舟云学术

Structure-Aided Design of Novel Inhibitors of HIV Protease Based on a Benzodiazepine Scaffold

Published:2012-10-23 Issue:22 Volume:55 Page:10130-10135
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Schimer Jiří¹,Cígler Petr¹,Veselý Jan,Grantz Šašková Klára¹,Lepšík Martin¹,Brynda Jiří¹²,Řezáčová Pavlína¹²,Kožíšek Milan¹,Císařová Ivana,Oberwinkler Heike³,Kraeusslich Hans-Georg³,Konvalinka Jan¹

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Gilead Sciences and IOCB Research Center, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10, Prague 6, Czech Republic

2. Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 4, Czech Republic

3. Department of Infectious Diseases, Virology, Heidelberg University, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301249q

Reference28 articles.

1. Active human immunodeficiency virus protease is required for viral infectivity.

2. Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance

3. Molecular basis of human immunodeficiency virus drug resistance: An update