3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase-Reference-Cited by-同舟云学术

3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Published:2006-01-10 Issue:3 Volume:49 Page:971-983
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tedesco Rosanna¹,Shaw Antony N.¹,Bambal Ramesh¹,Chai Deping¹,Concha Nestor O.¹,Darcy Michael G.¹,Dhanak Dashyant¹,Fitch Duke M.¹,Gates Adam¹,Gerhardt Warren G.¹,Halegoua Dina L.¹,Han Chao¹,Hofmann Glenn A.¹,Johnston Victor K.¹,Kaura Arun C.¹,Liu Nannan¹,Keenan Richard M.¹,Lin-Goerke Juili¹,Sarisky Robert T.¹,Wiggall Kenneth J.¹,Zimmerman Michael N.¹,Duffy Kevin J.¹

Affiliation:

1. Departments of Medicinal Chemistry and Drug Metabolism and Pharmacokinetics, The Musculoskeletal, Microbial and Proliferative Diseases Center of Excellence for Drug Discovery, Computational, Analytical and Structural Sciences (CASS), the Department of Virology, The Metabolic and Viral Diseases Center of Excellence for Drug Discovery, and Discovery Research, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050855s

Reference24 articles.

1. An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

2. CDC Hepatitis C Fact Sheet 2003http://www.cdc.gov/ncidod/diseases/hepatitis/c/cfact.pdf.

3. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

4. Current therapy and new molecular approaches to antiviral treatment and prevention of hepatitis C

5. People

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