Human Cytochrome P450 1A2 Involvement in the Formation of Reactive Metabolites from a Species-Specific Hepatotoxic Pyrazolopyrimidine Derivative, 5-n-Butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine-Reference-Cited by-同舟云学术

Human Cytochrome P450 1A2 Involvement in the Formation of Reactive Metabolites from a Species-Specific Hepatotoxic Pyrazolopyrimidine Derivative, 5-n-Butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine

Published:2009-01-12 Issue:2 Volume:22 Page:323-331
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Kuribayashi Shunji¹,Goto Kiyoto¹,Naito Shinsaku¹,Kamataki Tetsuya¹,Yamazaki Hiroshi¹

Affiliation:

1. Nutrient/Drug Metabolism and Pharmacology, Otsuka Pharmaceutical Factory, Inc., 115 Tateiwa, Muya-cho, Naruto, Tokushima 772-8601, Japan, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan, and Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx8003592

Reference27 articles.

1. Human Cytochrome P450 Enzymes

2. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus

3. In Vitro Metabolism of 2-Acetylbenzothiophene: Relevance to Zileuton Hepatotoxicity

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