Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity1
Author:
Affiliation:
1. Drug Metabolism Research, Discovery Chemistry, and Investigative Toxicology, Pharmacia & Upjohn, Inc., 301 Henrietta Street, Kalamazoo, Michigan 49001
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx960092z
Reference31 articles.
1. Synthesis of Novel 2,4-Diaminopyrrolo[2,3-d]pyrimidines with Antioxidant, Neuroprotective, and Antiasthma Activity
2. Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma
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