1. SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, Herts AL6 9AR, U.K., SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406-0939, and SmithKline Beecham Pharmaceuticals, Coldharbour Road, Harlow, Essex CM12 5AD, U.K.