5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: Novel and Selective Inhibitors of the Vacuolar H+-ATPase of Osteoclasts with Bone Antiresorptive Activity-Reference-Cited by-同舟云学术

5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: Novel and Selective Inhibitors of the Vacuolar H+-ATPase of Osteoclasts with Bone Antiresorptive Activity

Published:1998-04-21 Issue:10 Volume:41 Page:1568-1573
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gagliardi Stefania¹,Nadler Guy¹,Consolandi Emanuela¹,Parini Carlo¹,Morvan Marcel¹,Legave Marie-Nöelle¹,Belfiore Pietro¹,Zocchetti Andrea¹,Clarke Geoffrey D.¹,James Ian¹,Nambi Ponnal¹,Gowen Maxine¹,Farina Carlo¹

Affiliation:

1. Departments of Chemistry and Biology, SmithKline Beecham S.p.A., Via Zambeletti, 20021 Baranzate, Milano, Italy, Department of Medicinal Chemistry, SmithKline Beecham Research Unit, B.P. 58, 35762 St-Gregoire Cedex, France, and Departments of Bone and Cartilage Biology and Renal Pharmacology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406-0939

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9800144

Reference31 articles.

1. Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

2. Histamine release from rat peritoneal mast cells and human basophils induced by the free radical generator 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH)

3. Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump

4. Characterization of the Osteoclast Ruffled Border Chloride Channel and Its Role in Bone Resorption

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