Effects of the Pathological Q212P Mutation on Human Prion Protein Non-Octarepeat Copper-Binding Site

Author:

D’Angelo Paola1,Della Longa Stefano2,Arcovito Alessandro3,Mancini Giordano4,Zitolo Andrea1,Chillemi Giovanni4,Giachin Gabriele5,Legname Giuseppe567,Benetti Federico56

Affiliation:

1. Department of Chemistry, University of Rome “La Sapienza”, P.le Aldo Moro 5, I-00185 Rome, Italy

2. Dipartimento di Medicina Clinica, Sanità Pubblica, Scienze della Vita e dell'Ambiente, Università dell’Aquila, I- 67100 L’Aquila, Italy

3. Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, L.go F. Vito 1, I-00168 Rome, Italy

4. CASPUR, Consortium for Supercomputing Applications,Via dei Tizii 6b, I-00185 Rome, Italy

5. Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, I-34136 Trieste, Italy

6. SISSA Unit, Italian Institute of Technology, Via Bonomea 265, I-34136 Trieste, Italy

7. ELETTRA Laboratory, Sincrotrone Trieste S.C.p.A., I-34149, Basovizza, Trieste, ITALY

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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