Antibody Recognition of Melphalan Adducts Characterized Using Immobilized DNA: Enhanced Alkylation of G-Rich Regions in Cells Compared to in Vitro-Reference-Cited by-同舟云学术

Antibody Recognition of Melphalan Adducts Characterized Using Immobilized DNA: Enhanced Alkylation of G-Rich Regions in Cells Compared to in Vitro

Published:2000-12-15 Issue:1 Volume:14 Page:71-81
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

McCartney Hazel¹,Martin Anthea M.¹,Middleton Peter G.¹,Tilby Michael J.¹

Affiliation:

1. Cancer Research Unit and Department of Haematology, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, U.K.

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx000178z

Reference44 articles.

1. International Agency for Research on Cancer (1987)IARC monographs on the evaluation of carcinogenic risks to humans. Supplement 7, pp 39−43, International Agency for Research on Cancer, Lyon, France.

2. Tilby, M. J., Lawley, P. D., and Farmer, P. B. (1990) Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: characterization of mono-alkylated and cross-linked products from reaction of melphalan with dGMP and GMP.Chem.Biol. Interact.73, 183−194.

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