Discovery of Novel Hydroxamates as Highly Potent Tumor Necrosis Factor-α Converting Enzyme Inhibitors: Part I—Discovery of Two Binding Modes-Reference-Cited by-同舟云学术

Discovery of Novel Hydroxamates as Highly Potent Tumor Necrosis Factor-α Converting Enzyme Inhibitors: Part I—Discovery of Two Binding Modes

Published:2008-02-01 Issue:4 Volume:51 Page:725-736
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhu Zhaoning¹,Mazzola Robert¹,Sinning Lisa¹,McKittrick Brian¹,Niu Xiaoda¹,Lundell Daniel¹,Sun Jing¹,Orth Peter¹,Guo Zhuyan¹,Madison Vincent¹,Ingram Richard¹,Beyer Brian M.¹

Affiliation:

1. Departments of Medicinal Chemistry and Inflammation and Infectious Diseases, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070376o

Reference45 articles.

1. Characterization of the tumour necrosis factor α-converting enzyme, TACE/ADAM17

2. The Pathophysiology of Tumor Necrosis Factors

3. Anti-TNF agents in Crohn’s disease

4. The therapeutic potential of small molecule TACE inhibitors

5. TACE inhibition: a new approach to treating inflammation

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