Study of the Structural and Dynamic Effects in the FimH Adhesin upon α-d-Heptyl Mannose Binding-Reference-Cited by-同舟云学术

Study of the Structural and Dynamic Effects in the FimH Adhesin upon α-d-Heptyl Mannose Binding

Published:2014-02-07 Issue:4 Volume:57 Page:1416-1427
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vanwetswinkel Sophie¹²,Volkov Alexander N.¹²,Sterckx Yann G. J.¹²,Garcia-Pino Abel¹²,Buts Lieven¹²,Vranken Wim F.¹²,Bouckaert Julie²,Roy René³,Wyns Lode¹²,van Nuland Nico A. J.¹²

Affiliation:

1. Jean Jeener NMR Centre, Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium

2. Molecular Recognition Unit, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium

3. Department of Chemistry, Université du Québec à Montréal, P.O. Box 8888, Succ. Centre-Ville, Montréal (QC), Canada H3C 3P8

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401666c

Reference45 articles.

1. Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

2. The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin FimH

3. FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

4. Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

5. Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists

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