Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles

Author:

Nagarajan Muthukaman1,Morrell Andrew1,Ioanoviciu Alexandra1,Antony Smitha1,Kohlhagen Glenda1,Agama Keli1,Hollingshead Melinda1,Pommier Yves1,Cushman Mark1

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, and the Purdue Cancer Center, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, and Biological Testing Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Fairview Center, Suite 205...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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