Explanation for Main Features of Structure–Genotoxicity Relationships of Aromatic Amines by Theoretical Studies of Their Activation Pathways in CYP1A2-Reference-Cited by-同舟云学术

Explanation for Main Features of Structure–Genotoxicity Relationships of Aromatic Amines by Theoretical Studies of Their Activation Pathways in CYP1A2

Published:2011-09-21 Issue:40 Volume:133 Page:16168-16185
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Shamovsky Igor¹,Ripa Lena¹,Börjesson Lena¹,Mee Christine²,Nordén Bo¹,Hansen Peter¹,Hasselgren Catrin³,O’Donovan Mike²,Sjö Peter¹

Affiliation:

1. Department of Medicinal Chemistry, R&I iMed, AstraZeneca R&D, Pepparedsleden 1, S-431 83 Mölndal, Sweden

2. Genetic Toxicology, AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom

3. Global Safety Assessment, AstraZeneca R&D, S-431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja206427u

Reference117 articles.

1. An update on the genotoxicity and carcinogenicity of marketed pharmaceuticals with reference to in silico predictivity

2. Known drug space as a metric in exploring the boundaries of drug-like chemical space

3. Comparative Evaluation ofin SilicoSystems for Ames Test Mutagenicity Prediction: Scope and Limitations

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