An Improved Industrial Synthesis of Florfenicol plus an Enantioselective Total Synthesis of Thiamphenicol and Florfenicol
Author:
Affiliation:
1. Chemical Process Research and Development, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo961479%2B
Reference17 articles.
1. New Antibacterial Agents. 2-Acylamino-1-(4-hydrocarbonylsulfonylphenyl)-1,3-propanediols and Related Compounds
2. Jacquez, J.; Collet, A.; Wilen, S. InEnatiomers, Racemates, andResolutions; John Wiley and Sons: New York, 1981; p 223.
3. New strategy for racemization of 2-amino-1,3-propanediols, key intermediates for the synthesis of antibiotic drugs
4. Direct conversion of (1S,2S)-2-amino-1-[(4-methylthio)phenyl]-1,3-propanediol into its enantiomer for efficient synthesis of thiamphenicol and florfenicol
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