Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductases by 2,4-Diamino-5-[2-methoxy-5-(ω-carboxyalkyloxy)benzyl]pyrimidines: Marked Improvement in Potency Relative to Trimethoprim and Species Selectivity Relative to Piritrexim-Reference-Cited by-同舟云学术

Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductases by 2,4-Diamino-5-[2-methoxy-5-(ω-carboxyalkyloxy)benzyl]pyrimidines: Marked Improvement in Potency Relative to Trimethoprim and Species Selectivity Relative to Piritrexim

Published:2001-12-06 Issue:1 Volume:45 Page:233-241
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rosowsky Andre¹,Forsch Ronald A.¹,Queener Sherry F.¹

Affiliation:

1. Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, and the Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010407u

Reference54 articles.

1. Drug Treatment of HIV-Related Opportunistic Infections

2. Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocystis carinii pneumonia in AIDS

3. Oral Therapy forPneumocystis cariniiPneumonia in the Acquired Immunodeficiency Syndrome

4. Comparison of Atovaquone (566C80) with Trimethoprim-Sulfamethoxazole to Treat Pneumocystis carinii Pneumonia in Patients with AIDS

5. Comparison of Three Regimens for Treatment of Mild to Moderate Pneumocystis carinii Pneumonia in Patients with AIDS: A Double-Blind, Randomized Trial of Oral Trimethoprim-Sulfamethoxazole, Dapsone-Trimethoprim, and Clindamycin-Primaquine

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