Development of an Asymmetric Synthesis of a Chiral Quaternary FLAP Inhibitor
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Published:2015-01-22
Issue:3
Volume:80
Page:1651-1660
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ISSN:0022-3263
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Container-title:The Journal of Organic Chemistry
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language:en
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Short-container-title:J. Org. Chem.
Author:
Fandrick Keith R.1, Mulder Jason A.1, Patel Nitinchandra D.1, Gao Joe1, Konrad Michael1, Archer Elizabeth1, Buono Frederic G.1, Duran Adil1, Schmid Rolf1, Daeubler Juergen1, Desrosiers Jean-Nicolas1, Zeng Xingzhong1, Rodriguez Sonia1, Ma Shengli1, Qu Bo1, Li Zhibin1, Fandrick Daniel R.1, Grinberg Nelu1, Lee Heewon1, Bosanac Todd1, Takahashi Hidenori1, Chen Zhidong1, Bartolozzi Alessandra1, Nemoto Peter1, Busacca Carl A.1, Song Jinhua J.1, Yee Nathan K.1, Mahaney Paige E.1, Senanayake Chris H.1
Affiliation:
1. Department
of Chemical Development, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Reference58 articles.
1. World Heart Day 2002 2. 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor 3. Effects of a 5-Lipoxygenase–Activating Protein Inhibitor on Biomarkers Associated With Risk of Myocardial Infarction 4. Treatment With 5-Lipoxygenase Inhibitor VIA-2291 (Atreleuton) in Patients With Recent Acute Coronary Syndrome 5. aBartolozzi, A.; Bosanac, T.; Chen, Z.; De Lombaert, S.; Huber, J.; Lo, H. Y.; Loke, P. L.; Weimin, L.; Morwick, T. M.; Olague, A.; Riether, D.; Tye, H.; Wu, L.; Zindell, R.(Boehringer Ingelheim International GMBH) WO 2012/024150 A1, 2012.
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