Antibody-Directed Enzyme Prodrug Therapy with the T268G Mutant of Human Carboxypeptidase A1: In Vitro and in Vivo Studies with Prodrugs of Methotrexate and the Thymidylate Synthase Inhibitors GW1031 and GW1843-Reference-Cited by-同舟云学术

Antibody-Directed Enzyme Prodrug Therapy with the T268G Mutant of Human Carboxypeptidase A1: In Vitro and in Vivo Studies with Prodrugs of Methotrexate and the Thymidylate Synthase Inhibitors GW1031 and GW1843

Published:1999-01-01 Issue:1 Volume:10 Page:38-48
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Wolfe L. A.¹,Mullin R. J.¹,Laethem R.¹,Blumenkopf T. A.¹,Cory M.¹,Miller J. F.¹,Keith B. R.¹,Humphreys J.¹,Smith G. K.¹

Affiliation:

1. Glaxo Wellcome Research and Development Inc., Five Moore Drive, Research Triangle Park, North Carolina 27709

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc980057z

Reference36 articles.

1. Activation of prodrugs by antibody‐enzyme conjugates: a new approach to cancer therapy

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