Discovery and Synthesis of HIV Integrase Inhibitors: Development of Potent and Orally Bioavailable N-Methyl Pyrimidones-Reference-Cited by-同舟云学术

Discovery and Synthesis of HIV Integrase Inhibitors: Development of Potent and Orally Bioavailable N-Methyl Pyrimidones

Published:2007-09-08 Issue:20 Volume:50 Page:4953-4975
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gardelli Cristina¹,Nizi Emanuela¹,Muraglia Ester¹,Crescenzi Benedetta¹,Ferrara Marco¹,Orvieto Federica¹,Pace Paola¹,Pescatore Giovanna¹,Poma Marco¹,Rico Ferreira Maria del Rosario¹,Scarpelli Rita¹,Homnick Carl F.¹,Ikemoto Norihiro¹,Alfieri Anna¹,Verdirame Maria¹,Bonelli Fabio¹,Gonzalez Paz Odalys¹,Taliani Marina¹,Monteagudo Edith¹,Pesci Silvia¹,Laufer Ralph¹,Felock Peter¹,Stillmock Kara A.¹,Hazuda Daria¹,Rowley Michael¹,Summa Vincenzo¹

Affiliation:

1. Departments of Medicinal Chemistry and Pharmacology - Istituto Di Ricerche Di Biologia Molecolare, P. Angeletti S.p.A. (IRBM-MRL Rome), Via Pontina Km 30,600, 00040 Pomezia, Italy, Department of Medicinal Chemistry, Merck Research Laboratory, West Point, Pennsylvania, Department of Process Research, Merck Research Laboratory, Rahway, New Jersey, and Department of Antiviral Research, Merck Research Laboratory, West Point, Pennsylvania

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0704705

Reference46 articles.

1. HIV-1 Reverse Transcriptase: A Therapeutical Target in the Spotlight

2. HIV-1 Reverse Transcriptase Inhibitors: Current Issues and Future Perspectives

3. Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors

4. Nucleoside and nucleotide inhibitors of HIV-1 replication

5. Approaches to the Design of Effective HIV-1 Protease Inhibitors

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