A Ureido-Thioisobutyric Acid (GW9578) Is a Subtype-Selective PPARα Agonist with Potent Lipid-Lowering Activity-Reference-Cited by-同舟云学术

A Ureido-Thioisobutyric Acid (GW9578) Is a Subtype-Selective PPARα Agonist with Potent Lipid-Lowering Activity

Published:1999-09-01 Issue:19 Volume:42 Page:3785-3788
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brown Peter J.¹,Winegar Deborah A.¹,Plunket Kelli D.¹,Moore Linda B.¹,Lewis Michael C.¹,Wilson Joan G.¹,Sundseth Scott S.¹,Koble Cecilia S.¹,Wu Zhengdong¹,Chapman James M.¹,Lehmann Jürgen M.¹,Kliewer Steven A.¹,Willson Timothy M.¹

Affiliation:

1. Departments of Medicinal Chemistry, Metabolic Diseases, and Molecular Endocrinology, Glaxo Wellcome Research & Development, Research Triangle Park, North Carolina 27709, and College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9903601

Reference23 articles.

1. Efficacy and Safety in Phase II Trials

2. Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism

3. Treatment effects on serum lipoprotein lipids, apolipoproteins and low density lipoprotein particle size and relationships of lipoprotein variables to progression of coronary artery disease in the Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT)

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