Hydrophobic Effect and Hydrogen Bonds Account for the Improved Activity of a Complement Inhibitor, Compstatin-Reference-Cited by-同舟云学术

Hydrophobic Effect and Hydrogen Bonds Account for the Improved Activity of a Complement Inhibitor, Compstatin

Published:2006-07-01 Issue:15 Volume:49 Page:4616-4622
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Katragadda Madan¹,Magotti Paola¹,Sfyroera Georgia¹,Lambris John D.¹

Affiliation:

1. Protein Chemistry Laboratory, Department of Pathology & Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0603419

Reference29 articles.

1. Compstatin inhibits complement activation by binding to the β-chain of complement factor 3

2. Complement: more than a ‘guard’ against invading pathogens?

3. Compstatin Inhibits Complement and Cellular Activation in Whole Blood in Two Models of Extracorporeal Circulation

4. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts

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