Structure–Activity Relationship of Nonacidic Quinazolinone Inhibitors of Human Microsomal Prostaglandin Synthase 1 (mPGES 1)-Reference-Cited by-同舟云学术

Structure–Activity Relationship of Nonacidic Quinazolinone Inhibitors of Human Microsomal Prostaglandin Synthase 1 (mPGES 1)

Published:2012-04-11 Issue:8 Volume:55 Page:3792-3803
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rörsch Florian¹,Buscató Estel.la²,Deckmann Klaus¹,Schneider Gisbert³,Schubert-Zsilavecz Manfred²,Geisslinger Gerd¹,Proschak Ewgenij²,Grösch Sabine¹

Affiliation:

1. Johann Wolfgang Goethe-University, Institute of Clinical Pharmacology, pharmazentrum frankfurt, LiFF/ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany

2. Johann Wolfgang Goethe-University, Institute of Pharmaceutical Chemistry, LiFF/ZAFES, Max-von-Laue-Strasse 9, D-60438 Frankfurt/Main, Germany

3. ETH Zürich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201687d

Reference45 articles.

1. Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

2. Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1

3. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

4. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

5. Eicosanoids and cancer

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