Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design
Author:
Affiliation:
1. Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml200117z
Reference20 articles.
1. The metabolism of alicyclic amines to reactive iminium ion intermediates
2. Drug Approvals and Databases, U.S. Food and Drug Administration, http://www.fda.gov/Drugs/InformationOnDrugs.
3. Cytochrome P450
4. Excretion and metabolism of lorcainide in rats, dogs and man
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