Mutation of Nonessential Cysteines Shows That the NF-κB Essential Modulator Forms a Constitutive Noncovalent Dimer That Binds IκB Kinase-β with High Affinity
Author:
Affiliation:
1. Department of Chemistry and ‡Department of Biology, Boston University, Boston, Massachusetts 02215, United States
Funder
NIH Office of the Director
NSF Office of the Director
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi401368r
Reference58 articles.
1. Introduction to NF-κB: players, pathways, perspectives
2. IKK-γ is an essential regulatory subunit of the IκB kinase complex
3. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
4. Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation
5. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
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