Synthesis, Biophysical, and Pharmacological Evaluation of the Melanocortin Agonist AST3-88: Modifications of Peptide Backbone at Trp 7 Position Lead to a Potent, Selective, and Stable Ligand of the Melanocortin 4 Receptor (MC4R)-Reference-Cited by-同舟云学术

Synthesis, Biophysical, and Pharmacological Evaluation of the Melanocortin Agonist AST3-88: Modifications of Peptide Backbone at Trp 7 Position Lead to a Potent, Selective, and Stable Ligand of the Melanocortin 4 Receptor (MC4R)

Published:2014-08-26 Issue:10 Volume:5 Page:1020-1031
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Singh Anamika¹,Dirain Marvin L.,Wilczynski Andrzej,Chen Chi,Gosnell Blake A.,Levine Allen S.,Edison Arthur S.,Haskell-Luevano Carrie¹

Affiliation:

1. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/cn5000953

Reference61 articles.

1. The Cloning of a Family of Genes That Encode the Melanocortin Receptors

2. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA

3. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

4. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

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