Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization-Reference-Cited by-同舟云学术

Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

Published:2007-04-20 Issue:10 Volume:50 Page:2310-2318
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Prongay Andrew J.¹,Guo Zhuyan¹,Yao Nanhua¹,Pichardo John¹,Fischmann Thierry¹,Strickland Corey¹,Myers Joseph¹,Weber Patricia C.¹,Beyer Brian M.¹,Ingram Richard¹,Hong Zhi¹,Prosise Winifred W.¹,Ramanathan Lata¹,Taremi S. Shane¹,Yarosh-Tomaine Taisa¹,Zhang Rumin¹,Senior Mary¹,Yang Rong-Sheng¹,Malcolm Bruce¹,Arasappan Ashok¹,Bennett Frank¹,Bogen Stephane L.¹,Chen Kevin¹,Jao Edwin¹,Liu Yi-Tsung¹,Lovey Raymond G.¹,Saksena Anil K.¹,Venkatraman Srikanth¹,Girijavallabhan Viyyoor¹,Njoroge F. George¹,Madison Vincent¹

Affiliation:

1. Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060173k

Reference36 articles.

1. Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C

2. Interferon Alfa-2b Alone or in Combination with Ribavirin for the Treatment of Relapse of Chronic Hepatitis C

3. Peginterferon Alfa-2a in Patients with Chronic Hepatitis C

4. Peginterferon Alfa-2a in Patients with Chronic Hepatitis C and Cirrhosis

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