Design and Synthesis of Novel α1a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidine Moiety-Reference-Cited by-同舟云学术

Design and Synthesis of Novel α1a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidine Moiety

Published:1999-10-27 Issue:23 Volume:42 Page:4778-4793
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Murali Dhar T. G.¹,Nagarathnam Dhanapalan¹,Marzabadi Mohammad R.¹,Lagu Bharat¹,Wong Wai C.¹,Chiu George¹,Tyagarajan Sriram¹,Miao Shou Wu¹,Zhang Fengqi¹,Sun Wanying¹,Tian Dake¹,Shen Quanrong¹,Zhang Jack¹,Wetzel John M.¹,Forray Carlos¹,Chang Raymond S. L.¹,Broten Theodore P.¹,Schorn Terry W.¹,Chen Tsing Bao¹,O'Malley Stacy¹,Ransom Richard¹,Schneck Kathryn¹,Bendesky Robert¹,Harrell Charles M.¹,Vyas Kamlesh P.¹,Zhang Kanyin¹,Gilbert John¹,Pettibone Douglas J.¹,Patane Michael A.¹,Bock Mark G.¹,Freidinger Roger M.¹,Gluchowski Charles¹

Affiliation:

1. Departments of Chemistry and Pharmacology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, and Departments of Pharmacology, Drug Metabolism, and Medicinal Chemistry, Merck & Company, Inc., West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990201h

Reference25 articles.

1. Discovery of .alpha.1a-Adrenergic Receptor Antagonists Based on the L-Type Ca2+ Channel Antagonist Niguldipine

2. Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia

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