Tandem Enantioselective Conjugate Addition−Cyclopropanation. Application to Natural Products Synthesis

Author:

Alexakis Alexandre1,March Sébastien1

Affiliation:

1. Department of Organic Chemistry, University of Geneva, 30 quai Ernest-Ansermet, Geneva 4, Switzerland CH-1211

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference41 articles.

1. For recent reviews see:  (a) Alexakis, A.; Benhaim, C.Eur. J. Org.Chem.2002, 3221. (b) Krause, N.; Hoffmann-Röder, A.Synthesis2001, 171. (c) Sibi, M. P.; Manyem, S.Tetrahedron2000,56, 8033. (d) Tomioka, K.; Nagaoka, Y. InComprensive Asymmetric Catalysis I−III; Jacobsen, E. N., Pfaltz, A., Yamamoto, H., Eds.; Springer:  New York, 1999; p 1105.

2. Copper-mediated asymmetric transformations

3. Efficient Cu-Catalyzed Asymmetric Conjugate Additions of Alkylzincs to Trisubstituted Cyclic Enones

4. Modular Peptide-Based Phosphine Ligands in Asymmetric Catalysis:  Efficient and Enantioselective Cu-Catalyzed Conjugate Additions to Five-, Six-, and Seven-Membered Cyclic Enones

5. Novel Biphenol Phosphoramidite Ligands for the Enantioselective Copper-Catalyzed Conjugate Addition of Dialkyl zincs

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