1. Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013, ROC, Division of Medical Engineering, National Health Research Institutes, Taipei, Taiwan 11472, ROC, Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan 11217, ROC, and Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan