Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages

Author:

Zou Bin1,Nagle Advait2,Chatterjee Arnab K.2,Leong Seh Yong1,Tan Liying Jocelyn1,Sim Wei Lin Sandra1,Mishra Pranab2,Guntapalli Prasuna2,Tully David C.2,Lakshminarayana Suresh B.1,Lim Chek Shik1,Tan Yong Cheng1,Abas Siti Nurdiana1,Bodenreider Christophe1,Kuhen Kelli L.2,Gagaring Kerstin2,Borboa Rachel2,Chang Jonathan2,Li Chun2,Hollenbeck Thomas2,Tuntland Tove2,Zeeman Anne-Marie3,Kocken Clemens H. M.3,McNamara Case2,Kato Nobutaka2,Winzeler Elizabeth A.24,Yeung Bryan K. S.1,Diagana Thierry T.1,Smith Paul W.1,Roland Jason2

Affiliation:

1. Novartis Institute for Tropical Diseases, 10 Biopolis Road #05-01 Chromos, 138670 Singapore

2. Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, United States

3. Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands

4. Department of Pediatrics, School of Medicine, University of California, San Diego, California 92093, United States

Funder

Wellcome Trust

Medicines for Malaria Venture

Swiss Tropical and Public Health Institute

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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