β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site-Reference-Cited by-同舟云学术

β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site

Published:2018-04-20 Issue:18 Volume:140 Page:5914-5924
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zheng Jianbin¹²,Chen Long¹,Skinner Owen S.³,Ysselstein Daniel¹,Remis Jonathan⁴,Lansbury Peter⁵,Skerlj Renato⁵,Mrosek Michael⁶,Heunisch Ursula⁶,Krapp Stephan⁶,Charrow Joel⁷,Schwake Michael¹,Kelleher Neil L.³^ORCID,Silverman Richard B.²,Krainc Dimitri¹^ORCID

Affiliation:

1. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States

2. Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States

3. Department of Chemistry and Molecular Biosciences, and Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States

4. Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States

5. Lysosomal Therapeutics Inc., 19 Blackstone Street, Cambridge, Massachusetts 02139, United States

6. Proteros Biostructures GmbH, Bunsenstrasse 7a, Martinsried 82152, Germany

7. Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States

Funder

National Institute of Neurological Disorders and Stroke

Division of Graduate Education

Deutsche Forschungsgemeinschaft

W. M. Keck Foundation

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)