Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2-Reference-Cited by-同舟云学术

Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2

Published:2018-02-07 Issue:7 Volume:140 Page:2493-2503
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Yang Jie¹²,Dear Alexander J.³,Michaels Thomas C. T.³⁴,Dobson Christopher M.³,Knowles Tuomas P. J.³⁵^ORCID,Wu Si¹²,Perrett Sarah¹²^ORCID

Affiliation:

1. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China

2. University of the Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, China

3. Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom

4. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States

5. Cavendish Laboratory, J J Thomson Avenue, Cambridge CB3 1HE, United Kingdom

Funder

Engineering and Physical Sciences Research Council

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Ministry of Science and Technology of the People's Republic of China

Frances and Augustus Newman Foundation

National Natural Science Foundation of China

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

Chinese Academy of Sciences

Schiff Foundation

Centre for Misfolding Diseases, University of Cambridge

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.7b10439

Reference72 articles.

1. Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

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4. Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

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