The Opioid μ Agonist/δ Antagonist DIPP-NH2[Ψ] Produces a Potent Analgesic Effect, No Physical Dependence, and Less Tolerance than Morphine in Rats-Reference-Cited by-同舟云学术

The Opioid μ Agonist/δ Antagonist DIPP-NH2[Ψ] Produces a Potent Analgesic Effect, No Physical Dependence, and Less Tolerance than Morphine in Rats

Published:1999-08-05 Issue:18 Volume:42 Page:3520-3526
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Schiller Peter W.¹,Fundytus Marian E.¹,Merovitz Lisa¹,Weltrowska Grazyna¹,Nguyen Thi M.-D.¹,Lemieux Carole¹,Chung Nga N.¹,Coderre Terence J.¹

Affiliation:

1. Laboratory of Chemical Biology and Peptide Research and Pain Mechanisms Laboratory, Clinical Research Institute of Montreal,§ 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980724%2B

Reference24 articles.

1. Attenuation of morphine tolerance and dependence with the highly selective δ-opioid receptor antagonist TIPP[ψ]

2. Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

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