Synthesis of Difluoromethylated Carbinols via a HFIP-Promoted Hydroxydifluoromethylation of Aniline, Indole, and Pyrrole Derivatives with Difluoroacetaldehyde Ethyl Hemiacetal-Reference-Cited by-同舟云学术

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Synthesis of Difluoromethylated Carbinols via a HFIP-Promoted Hydroxydifluoromethylation of Aniline, Indole, and Pyrrole Derivatives with Difluoroacetaldehyde Ethyl Hemiacetal

Published:2023-03-29 Issue:7 Volume:88 Page:4790-4798
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Yang Jianguo¹²^ORCID,Gui Jing¹,Mu Miaomiao¹,Liu Saimei²,Li Jinshan¹^ORCID,Ren Jun²^ORCID,Wang Zhiming¹^ORCID

Affiliation:

1. Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P.R. China

2. Collaborative Innovation Center for Advanced Organic Chemical Materials Co-Constructed by the Province and Ministry, Hubei University, Wuhan 430062, P.R. China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

?Pioneer? and ?Leading Goose? R&D Program of Zhejiang

Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.2c02812

Reference36 articles.

1. CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?

2. Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

3. Applications of Fluorine in Medicinal Chemistry

4. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

5. Enantiomerically Pure and Highly Substituted Alicyclic α,α-Difluoro Ketones: Potential Inhibitors for Malarial Aspartic Proteases, the Plasmepsins

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1. Hexafluoroisopropanol (HFIP)-Mediated Intramolecular Cyclization of Allenamides To Access C1-Vinyl Tetrahydro-β-carbolines;The Journal of Organic Chemistry;2024-07-26

2. Transition-metal-free synthesis of triarylmethanes via Friedel-Crafts reactions of imidazo[1,2-a]pyridines with chlorohydrocarbon derivatives;Journal of Saudi Chemical Society;2024-07

3. HFIP-promoted synthesis of imidazo [1,2-a]pyridines containing CF3-substituted tertiary alcohols at room temperature;Tetrahedron;2024-04

4. Metal-Free Synthesis of Trifluoromethyl Carbinol-Containing Imidazo[1,2-a]pyridines via Dehydrative Coupling of Imidazo[1,2-a]pyridines with Trifluoroacetaldehyde;Synthesis;2024-01-25

5. Regio- and Stereoselective Hexafluoroisopropoxylation and Trifluoroethoxylation of Allenamides;The Journal of Organic Chemistry;2024-01-02

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