Functionalization of 2,4-Dichloropyrimidines by 2,2,6,6-Tetramethylpiperidyl Zinc Base Enables Modular Synthesis of Antimalarial Diaminopyrimidine P218 and Analogues-Reference-Cited by-同舟云学术

Functionalization of 2,4-Dichloropyrimidines by 2,2,6,6-Tetramethylpiperidyl Zinc Base Enables Modular Synthesis of Antimalarial Diaminopyrimidine P218 and Analogues

Published:2023-06-08 Issue:13 Volume:88 Page:9475-9487
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Meirelles Matheus A.¹^ORCID,de Toledo Ian¹,Thurow Samuel¹²,Barreiro Gabriela²,Couñago Rafael M.³^ORCID,Pilli Ronaldo A.¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Institute of Chemistry, University of Campinas, UNICAMP, 13083-970-Campinas, SP, Brazil

2. Eurofarma Laboratórios S/A, 06696-000-Itapevi, SP, Brazil

3. Center of Medicinal Chemistry (CQMED), University of Campinas, UNICAMP, 13083-886-Campinas, SP, Brazil

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c00500

Reference28 articles.

1. World Malaria Report 2021. Available at: https://www.who.int/teams/global-malaria-programe/reports/world-malaria-report-2021. Accessed December 08, 2022.

2. Antimalarial drug resistance

3. Evidence of Artemisinin-Resistant Malaria in Africa

4. New insights into antimalarial chemopreventive activity of antifolates

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