Enantioselective Synthesis of a γ-Secretase Modulator via Vinylogous Dynamic Kinetic Resolution

Author:

Strotman Neil A.1ORCID,Ramirez Antonio1,Simmons Eric M.1ORCID,Soltani Omid1,Parsons Andrew T.1ORCID,Fan Yu1,Sawyer James R.1,Rosner Thorsten1,Janey Jacob M.1,Tran Kristy1,Li Jun1,La Cruz Thomas E.1ORCID,Pathirana Charles1,Ng Alicia T.1,Deerberg Joerg1

Affiliation:

1. Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference45 articles.

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2. The  -Secretase Modulator, BMS-932481, Modulates A  Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

3. aBoy, K. M.; Guernon, J. M.; Macor, J. E.; Olson, R. E.; Shi, J.; Thompson, III, L. A.; Wu, Y.J.; Xu, L.; Zhang, Y.; Zuev, D. S. Compounds for the Reduction of β-Amyloid Production. Int. Patent WO 2011/014535 A1.

4. bBoy, K. M.; Guernon, J. M.; Macor, J. E.; Olson, R. E.; Shi, J.; Thompson, III, L. A.; Wu, Y.J.; Xu, L.; Zhang, Y.; Zuev, D. S. Compounds for the Reduction of β-Amyloid Production. Patent US 2012/0028994 A1.

5. Convenient synthesis of deazaflavin cofactor FO and its activity in F420-dependent NADP reductase

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