Synthesis of (R)-Boc-2-methylproline via a Memory of Chirality Cyclization. Application to the Synthesis of Veliparib, a Poly(ADP-ribose) Polymerase Inhibitor-Reference-Cited by-同舟云学术

Synthesis of (R)-Boc-2-methylproline via a Memory of Chirality Cyclization. Application to the Synthesis of Veliparib, a Poly(ADP-ribose) Polymerase Inhibitor

Published:2019-02-04 Issue:8 Volume:84 Page:4837-4845
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Kolaczkowski Lawrence¹^ORCID,Barkalow Jufang¹,Barnes David M.¹,Haight Anthony¹,Pritts Wayne²,Schellinger Adam²

Affiliation:

1. Process Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States

2. Process Analytical Chemistry, AbbVie, Inc., North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.8b02866

Reference34 articles.

1. ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

2. ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors

3. Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent/metastatic breast cancer: randomized phase II study

4. Randomized, Placebo-Controlled, Phase II Study of Veliparib in Combination with Carboplatin and Paclitaxel for Advanced/Metastatic Non–Small Cell Lung Cancer

5. Process Development for ABT-472, a Benzimidazole PARP Inhibitor

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