Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogues Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight-Reference-Cited by-同舟云学术

Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogues Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight

Published:2020-03-23 Issue:8 Volume:85 Page:5598-5614
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Wu Xiaofan¹,Huang Zedu²³^ORCID,Wang Zexu²³,Li Zhining²³,Wang Jiaqi²³,Lin Juan¹⁴^ORCID,Chen Fener²³^ORCID

Affiliation:

1. College of Chemical Engineering, Fuzhou University, Fuzhou 350116, P. R. China

2. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China

3. Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai 200433, P. R. China

4. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, P. R. China

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c00469

Reference46 articles.