Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2-C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens-Reference-Cited by-同舟云学术

Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2-C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens

Published:2018-06-05 Issue:17 Volume:83 Page:9580-9591
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Bartee David¹,Wheadon Michael J.¹,Freel Meyers Caren L.¹^ORCID

Affiliation:

1. Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States

Funder

National Institute of General Medical Sciences

Institute for Basic Biomedical Sciences, School of Medicine, Johns Hopkins University

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.8b00686

Reference29 articles.

1. Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate

2. Characterization of the Mycobacterium tuberculosis 4-Diphosphocytidyl-2- C -Methyl- d -Erythritol Synthase: Potential for Drug Development

3. The Methylerythritol Phosphate Pathway Is Functionally Active in All Intraerythrocytic Stages of Plasmodium falciparum

4. Isoprenoid biosynthesis in bacterial pathogens

5. Lipid Intermediates in the Biosynthesis of Bacterial Peptidoglycan

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